SETD2 is a protein well known as a chromatin remodeler, one that helps turn genes on or off by modifying histone proteins in the nucleus of the cell. When researchers discovered that SETD2 is mutated ...

The dynamic assembly and disassembly of actin filaments underpin essential cellular behaviours including migration, morphogenesis and division. Emerging evidence reveals that reversible ...

The actin cytoskeleton in Saccharomyces cerevisiae comprises a dynamic network of filamentous structures—cables, cortical patches and the cytokinetic ring—that underpins cell shape, polarity and ...

Researchers have developed photoresponsive derivatives of the anticancer drug Taxol®, which allow light-based control of cytoskeleton dynamics in neurons. The agents can optically pattern cell ...

For immune cells, the actin cytoskeleton is more than a structural scaffold. Immune cells can migrate to sites of infection or form precise, short-lived contacts with other cells, by constantly ...

SETD2, known for its involvement on gene expression, also can affect functions controlled by the cytoskeleton, such as movement, metastasis and migration, which are very important for cancer cells.