Scientists at the University of California, Santa Cruz, have trapped the ribosome, a protein-building molecular machine essential to all life, in a key transitional state that has long eluded ...

Elongation, a crucial step in the translation process of protein synthesis, gets disrupted by amino acid sequences with an abundance of N-terminal aspartic and glutamic acid residues in eukaryotic ...

tRNAs have a distinct cloverleaf secondary structure and an L-shaped tertiary structure. The cloverleaf structure is formed by the folding of the single-stranded tRNA molecule, which is typically ...

A novel study uncovers how a subtle chemical tweak transforms the naturally occurring phytotoxin into a powerful molecular glue, 12-deoxyfusicoccin (12-dFC), that locks 14-3-3 proteins onto the ...

A protein’s life is anything but simple. Discover how transcription, translation, folding, modification, and degradation work together to preserve proteome integrity.