Brain organoids, also known as brain spheroids, are three-dimensional cultures of neural cells derived from pluripotent stem cells (PSCs) that mimic the brain’s organization, development, and activity ...

Neuroscientist Roya Huang tells us about their experience of publishing in the eLife Model. Roya Huang is a Postdoctoral Fellow in the Department of Molecular and Cell Biology, University of ...

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Crystal structures of γ-protocadherin cell-cell recognition dimers reveal the determinants of clustered protocadherin homophilic specificity and cis interaction region structures alongside mutagenesis ...

Cryo-EM structures of 70S•RelA ribosome complexes reveal how cognate deacyl-tRNA activates RelA.

where ΔG (γ = 0) is the free energy difference at zero tension, γ the membrane tension and ΔA the in-plane cross sectional area change associated with channel opening (Haswell et al., 2011). Thus, ...

The structure of the calcium channel Orai in an open conformation reveals a dilated pore and gives insight into mechanisms of ion permeation and calcium selectivity.

To control reaching, the nervous system must generate large changes in muscle activation to drive the limb toward the target, and must also make smaller adjustments for precise and accurate behavior.

This is a thorough, beautiful and compelling study of the flagellar structure of the choanoflagellate S. rosetta as reconstituted by cryo-electron tomography (now one of the handful of eukaryotic ...

These are nicely done and very complete studies which provide strong evidence that medullary collecting duct cells survive periodic medullary toxicity through upregulation of SLC38A2 , an amino acid ...

Brain abnormalities in the reading network have been repeatedly reported in individuals with developmental dyslexia (DD); however, it is still not totally understood where the structural and ...

This work advances on two Aso et al 2014 eLife papers to describe further resources that are valuable for the field. This paper identified and contributes additional MBON split-Gal4s, convincingly ...